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KMID : 0357920030370040291
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Korean Journal of Pathology
2003 Volume.37 No. 4 p.291 ~ p.295
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Inflammatory Myofibroblastic Tumor(Inflammatory Fibrosarcoma) of the Lung - A Case Report -
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Eum Min-Seob
Kim Tae-Heon
Park Jin-Kyu
Park Kwang-Hwa
Jung Soon-Hee
Lee Kwang-Gil
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Abstract
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Inflammatory myofibroblastic tumor, also known as inflammatory fibrosarcoma, has been frequently diagnosed as inflammatory pseudotumor. Although there are six cases reported as inflammatory pseudotumors or inflammatory myofibroblastic tumors in the lung, no cases of pulmonary inflammatory myofibroblastic tumor with features of inflammatory fibrosarcoma have been reported in Korea. We experienced a case of inflammatory myofibroblastic tumor (inflammatory fibrosarcoma ) characterized by high cellularity, severe nuclear pleomorphism, necrosis, or increased mitotic counts. A 31-year-old male patient with a solitary pulmonary nodule on the routine chest x-ray received a right lower lobectomy. The tumor was an ovoid solid mass with multifocal necrosis, showing diffuse irregular proliferation of spindle cells with high cellularity and focal nuclear pleomorphism, admixed with dense lymphoplasmacytic cells. Although spindle cells are focally immunoreactive for smooth muscle actin, the ultrastructural examination failed to demonstrate smooth muscle differentiation. In cases of inflammatory myofibroblastic tumor (inflammatory fibrosarcoma), a complete excision and close follow-up without radical surgery, radiation, or chemotherapy are needed.
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KEYWORD
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Inflammatory Myofibroblastic Tumor, Inflammatory Fibrosarcoma, Inflammatory Pseudotumor, Lung
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